![]() The generation is performed with the RayDrop, a device developed and manufactured by Secoya. If the conditions are not optimum, deformed alginate beads or beads with tail could be produced, and this is a big limitation because in microbead production, particle size is key parameter.įollowing is a method for encapsulation of reagent into alginate microbeads with total control of bead formation. Although this method has been used for many years, formation of the beads with desired size and spherical-shaped often requires some trial-and-error work on the liquid formulation and experimental set-up (e.g., solution viscosity or surface tension, tip size, collecting distance etc.). In this method, the alginate solution is extruded through a capillary at a low volumetric rate and allowed to drip under gravity. The most popular way to produce mono-dispersed alginate microbeads is by using the dripping technique. The carrier qualities can be influenced by the alginate composition and concentration, the presence of impurities, the type and concentration of gelling ions and non-gelling ions as well as the production process conditions. Among the considerations are the size, size distribution, shape, mass transport properties, biocompatibility, swelling properties, solubility, and mechanical and chemical stability. The critical design considerations of alginate microbeads are highly dependent on the applications. Although there are multiple methods for the production, each presents numerous technical challenges, most commonly the high viscosity of the polymer fluids. The preparation method will determinate the type and the size of alginate microbead and influence the ability of the interaction among the components used in microbead formulations. Several methods and techniques are potentially useful for the preparation of polymeric microparticles in the broad field of microencapsulation, including extrusion, batch method or spray drying. Alginate microbeads are biodegradable, biocompatible, and non-toxic, which allows them to be used as drug delivery systems for controlled release of both hydrophobic and hydrophilic drugs. The gelation reaction can be manipulated to create wet or dry spherical beads for visual effect, encapsulation of other materials or agglomeration of powders. This technique has been employed in a diverse range of fields from chemicals and pharmaceuticals to cosmetics and printing.Īlginate is a natural polymer, extracted from seaweed, which is able to form a gel when dissolved in water and exposed to certain salts. Microencapsulation is a technique by which solid, liquid, or gaseous active ingredients are packaged within a second material for the purpose of shielding the active ingredient from the surrounding environment. Microfluidic Software control Read more How to produce mono-dispersed alginate microbeads?
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